07-Ghost takes place in a fantasy world with many special laws, kingdoms, gods and magic. The Empire Barsburg is divided into seven districts, each with its own cities, rulers, and their own culture. The seventh district is where the church is located, which is an inviolable sanctuary, where everyone can find refuge. This site is protected by seven Ghost which legends are only for residents.
Two pieces of theme music are used; Aka no Kakera by Yuki Suzuki is the opening theme, while Hitomi no Kotae by Noria is the ending theme. Teito Klein is a teenager who is preparing for his entrance exam to the army with his best friend Mikage. Teito has retained no memory of his childhood. But during the examination, the examiner for his Ayanami triggers a wave of memories.